The domain within your query sequence starts at position 421 and ends at position 560; the E-value for the 3a1a domain shown below is 8e-55.
SRERMASEVTNNKGNLEDRCLSCGKKNPVSFHPLFEGGLCQSCRDRFLELFYMYDEDGYQ SYCTVCCEGRELLLCSNTSCCRCFCVECLEVLVGAGTAEDAKLQEPWSCYMCLPQRCHGV LRRRKDWNMRLQDFFTTDPD